Panton-Valentine Leucocidin-Positive Staphylococcus aureus Nasal Carriers in a Tertiary Hospital in Selangor-Malaysia

Panton-Valentine Leukocidin (PVL) is a cytotoxin produced by Staphylococcus aureus that causes leukocyte destruction and tissue necrosis. Therefore, this study aimed to detect the rate, antimicrobial susceptibility, associated risk factors, phylogenetic relationship of PVL-positive S. nasal carriers among patients nurses. The research methods included collection 315 specimens obtained from inpatients identification was confirmed coagulase test. multiplex polymerase chain reaction technique used affirm aureus. antibiotic sensitivity isolates carried out using disk diffusion method. similarity identified pulsed-field gel electrophoresis. This revealed 160 (50.8%) were In addition, 7/160 (4.4%) had lukS gene (six MSSA one MRSA). 100% sensitive gentamicin, linezolid, mupirocin, rifampin, trimethoprim-sulfamethoxazole, teicoplanin, tigecycline, vancomycin. factor analysis longer hospital stay, nasogastric intubation, runny nose significant factors for be carriers. A showed five models they distantly correlated. current will provide knowledge infectious control authority.